Lisa Cameron

Dr. Lisa Cameron, PhD

Associate Professor

Western University


Education

  • PDF – University of Arizona 2000-2005
  • PhD – McGill University 1995-2000
  • BSc – McGill University 1991-1995

Research Interests

Our laboratory investigates molecular mechanisms of the allergic inflammatory process underlying disorders such as asthma, allergic rhinitis and atopic dermatitis. Currently we are studying the regulation of CRTh2 (chemotactic receptor homologous molecule expressed on Th2 cells), a marker for the Th2 lymphocytes, characteristic of allergic inflammation. CRTh2 is a receptor for prostaglandin D2 (PGD2), a lipid mediator derived from dietary sources of polyunsaturated fatty acids and released at the site of exposure by allergen activated mast cells. PGD2-CRTh2 signaling perpetuates the allergic cascade through inflammatory cell chemotaxis and by inducing further expression of the Th2 cytokines that mediate allergic inflammation, IL-4, IL-5 and IL-13.

PGD2-CRTh2 signalling maintains the Th2 phenotype

Projects involve examining:

i) transcriptional regulation of CRTh2, identifying the transcription factors involved in promoter activation and the cis-regulatory elements participating in gene regulation

ii) single nucleotide polymorphisms (SNPs) in CRTh2 that influence an individual’s susceptibility to develop allergic disorders and their functional impact on gene expression.

iii) gene-environment interactions with CRTh2, such as polyunsaturated fatty acid levels, since they arise from dietary sources and influence the immune system.

iv) novel mediators of Th2 cells we identified through whole genome microarray

Highlighted Publications

  • Cameron L., P. Christodoulopoulos, F. Lavigne, Y. Nakamura, D. Eidelman, A. McEuen, A. Walls, J. Tavernier, E. Minshall, R. Moqbel and Q. Hamid. 2000. Evidence for Local Eosinophil Differentiation within Allergic Nasal Mucosa: Inhibition with Soluble IL-5 Receptor. J. Immunol. 164:1538-1545. 

  • Cameron, L., Q. Hamid, E. Wright, S. Frenkiel, F. Lavigne, S. Durham and H. Gould. 2000. Local Synthesis of ε Germline Transcripts, IL-4 and IL-13 in Allergic Nasal Mucosa after Ex Vivo Allergen Exposure. J. Allergy Clin. Immunol. 106:46-52. 

  • Nakamura, Y, P. Christodoulopoulos, L. Cameron, E. Wright, F. Lavigne, M. Toda, S. Muro, A. Ray, D.H. Eidelman, E. Minsall and Q. Hamid. 2000. Upregulation of the Transcription Factor GATA-3 in Upper Airway Mucosa after In Vivo and In Vitro Allergen Challenge. J. Allergy Clin. Immunol. 105:1146-1152.

  • Christodoulopoulos, P., L. Cameron, Y. Nakamura, C. Lemiere, S. Muro, M. Dugas, L.P. Boulet, M. Laviolette, R. Olivenstein and Q. Hamid. 2001. Th2 Cytokine-Associated Transcription Factors in Atopic and Non-Atopic Asthma: Evidence for Differential Signal Transducer and Activator of Transcription 6 (STAT6) Expression. J. Allergy Clin. Immunol. 107:586-591.

  • Lavigne F, L. Cameron, P. Renzi, J.F. Planet, P. Christodoulopoulos, B. Lamkioued and Q. Hamid. 2002. Intrasinus Administration of Topical Budesonide to Allergic Patients with Chronic Rhinosinusitis Following Surgery. The Laryngoscope. 112: 858-864.

  • Cameron, L., A. Soussi Gounni, S. Frenkiel, F. Lavigne, D. Vercelli and Q. Hamid. 2003. SεSμ and SεSγ Switch Circles in Human Nasal Mucosa Following Ex Vivo Allergen Challenge: Evidence for Direct as well as Sequential Class Switch Recombination. J. Immunol. 171:3816-3822. 

  • Cameron, L, R. B. Webster, M. Kabesch, D.A. Stern, H. Ramachandran, L.Z. Yu, W. Klimecki and D. Vercelli. 2006. Th2 Cell-selective Enhancement of Human IL13 Transcription by IL13-1112C>T, a Polymorphism Associated with Allergic Inflammation J. Immunol. 177:8633-8642. 

  • Marcet-Palacios, M. Ulanova, F. Duta, L. Puttagunta, S. Munoz, D. Gibbings, M. Radomski, L. Cameron, I. Mayers, D.A. Befus. 2007. The Transcription Factor Wilms Tumor 1 Regulates Matrix Metalloproteinase-9 through a Nitric Oxide-Mediated Pathway. J. Immunol. 179:256-265. 

  • Quapp, R., N. Madsen, and L. Cameron. 2007. Characterization of the Promoter of Human CRTh2: a Prostaglandin D2 Receptor. Bioch Biophys Res Comm. 363:948-953. 

  • Schedel, M., L. Pinto, B. Schaub, P. Rosenstiel, D. Cherkasov, L. Cameron, N. Klopp, T. Illig, C. Vogelberg, S. Weiland, E. von Mutius, M. Lohoff and M. Kabesch. 2008. IRF-1 Gene Variations Influence IgE Regulation and Atopy. Am. J. Respir. Crit. Care Med. 177:613-621. 

  • Schedel, M., R. Frei, C. Bieli, L. Cameron, J. Adamski, R. Lauener and M. Kabesch. 2009. An IgE-Associated Polymorphism in STAT6 Alters NF-κB Binding, STAT6 Promoter Activity, and mRNA Expression. J. Allergy and Clin Immunol. 124(3):583-9. 

  • Cameron L., M. Depner, M. Kormann, N. Klopp, T. Illig, E. von Mutius and M. Kabesch. 2009. Genetic Variation in CRTh2 Influences Development of Allergic Phenotypes. Allergy. 64(10):1478-85. 

  • MacLean, E., N. Madsen, H. Vliagoftis, C. Field and L. Cameron. Omega-3 Fatty Acids Inhibit Transcription of Human IL-13: Implications for Development of Allergic Disease. Brit J Nutr (in press)

  • Campos Alberto, E., E. MacLean, C. Davidson, J. Storie, N.S. Palikhe, C. Tse, D. Brenner, I. Mayers, H. Vliagoftis, A. El-Sohemy, L. Cameron. The Single Nucleotide Polymorphism, CRTh2-6373G>A, is Associated with Allergic Asthma and Increased Expression of CRTh2 (under review, Allergy).

For a complete list of publications, click here.

Current Sources of Funding

  • Canadian Institutes of Health Research (CIHR)
  • Alberta Innovates – Health Solutions
  • GSK-CIHR Rx&D Chair in Airway Inflammation
  • CIHR-SickKids Foundation
  • AllerGen
  • National Sanatorium Association

Current Research Personnel

Staff

  • Courtney Davidson
  • Jessica Storie
  • Brenden Joseph

Trainees

Career Opportunities